Plasma metabolite profiling and chemometric analyses of tobacco snuff dippers and patients with oral cancer: Relationship between metabolic signatures.
Head Neck
; 41(2): 291-300, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30548891
ABSTRACT
BACKGROUND:
Cancer of oral cavity is a seriously growing problem in many parts of the world. In Indian subcontinent, most of these cases have been attributed to the use of tobacco-related products. This study is focused on the identification of distinguishing metabolites of oral cancer in comparison with tobacco snuff dippers and healthy controls.METHODS:
A total of 234 plasma samples including 62 healthy controls, 81 tobacco snuff dippers, and 91 oral cancer samples were analyzed using mass spectrometry.RESULTS:
Twenty-nine of 3326 metabolites were found to distinguish among oral cancer, tobacco snuff dippers, and healthy controls using P-value ≤.001 and fold change ≥3. Prediction model was generated with an overall accuracy of 89.3%. Two metabolites, that is, stearyl alcohol and sucrose, can be used as predictive biomarkers showing progression of tobacco snuff dippers toward oral cancer.CONCLUSION:
The unique metabolite profile gives evidence of a strong correlation between tobacco snuff dipping and oral cancer.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sacarose
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Neoplasias Bucais
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Tabaco sem Fumaça
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Ácidos Graxos
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Álcoois Graxos
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Uso de Tabaco
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article