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Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches.
Zeglinski, Matthew R; Moghadam, Adel Rezaei; Ande, Sudharsana R; Sheikholeslami, Kimia; Mokarram, Pooneh; Sepehri, Zahra; Rokni, Haleh; Mohtaram, Nima Khadem; Poorebrahim, Mansour; Masoom, Anahita; Toback, Mehnosh; Sareen, Niketa; Saravanan, Sekaran; Jassal, Davinder S; Hashemi, Mohammad; Marzban, Hassan; Schaafsma, Dedmer; Singal, Pawan; Wigle, Jeffrey T; Czubryt, Michael P; Akbari, Mohsen; Dixon, Ian M C; Ghavami, Saeid; Gordon, Joseph W; Dhingra, Sanjiv.
Afiliação
  • Zeglinski MR; St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
  • Moghadam AR; Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Ande SR; Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
  • Sheikholeslami K; Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Mokarram P; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Sepehri Z; Colorectal Research Center and Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Rokni H; Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Mohtaram NK; Department of Internal Medicine, Zabol University of Medical Sciences, Zabol, Iran.
  • Poorebrahim M; Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Masoom A; Laboratory for Innovation in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, British, Columbia, Canada.
  • Toback M; Department of System Design Engineering, Program of Biomedical Engineering, University of Waterloo.
  • Sareen N; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Saravanan S; Faculty of Medicine, Mashhad Islamic Azad University, Mashhad, Iran.
  • Jassal DS; Foothills Hospital, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada.
  • Hashemi M; St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
  • Marzban H; St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
  • Schaafsma D; CeNTAB, Department of Bioengineering, SCBT, SASTRA University, Thanjavur, India.
  • Singal P; St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
  • Wigle JT; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
  • Czubryt MP; Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Akbari M; Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Dixon IMC; St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
  • Ghavami S; St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
  • Gordon JW; St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
  • Dhingra S; Laboratory for Innovation in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, British, Columbia, Canada.
Compr Physiol ; 9(1): 75-125, 2018 12 13.
Article em En | MEDLINE | ID: mdl-30549015
Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. This review summarizes the signaling pathways implicated in the transition to HF following cardiac injury. In addition, we provide an update on cell death signaling and discuss recent advances in cardiac fibrosis as an independent event leading to HF. Finally, we discuss cell-based therapies and their possible use to avert the deteriorating nature of HF. © 2019 American Physiological Society. Compr Physiol 9:75-125, 2019.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Engenharia Tecidual / Medicina Regenerativa / Insuficiência Cardíaca Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Engenharia Tecidual / Medicina Regenerativa / Insuficiência Cardíaca Idioma: En Ano de publicação: 2018 Tipo de documento: Article