ytotoxic Constituents of Mallotus microcarpus.
Nat Prod Commun
; 12(3): 407-408, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-30549897
ABSTRACT
A new 3-methoxybenzensulfonic acid 4-0-0-D-glucopyranoside (1), and ten known compounds (2-11) were isolated from the methanolic extract of the stems of Mallotus microcarpus. The cytotoxicity of the isolated compounds was evaluated by the MTT method. 3-Methoxybenzensulfonic acid 4-Ο-ß-D- glucopyranoside (1) and methyl salicylate 2-rutinoside (5) showed strong cytotoxicity against EGFR-TKI-resistant human lung cancer A549 cells in comparison with camptothecin. Compound 1, leonuriside A (2), 3,4'-dihydroxypropiophenone 3-Ο-glucoside (6) and (lR,2S)-hovetrichoside A (10) inhibited the growth of human breast cancer MCF-7 cell line with IC50 values in the range of 0.48-1.78 µM. This is the first report on the chemical composition and cytotoxic activity of M microcarpus.
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Base de dados:
MEDLINE
Assunto principal:
Mallotus (Planta)
/
Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article