Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression.
Biomed Pharmacother
; 109: 930-937, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30551547
ABSTRACT
Endothelial cells are vital to blood coagulation and maintain whole body hemostasis. Binding of endothelial cells to endothelial protein C receptor (EPCR) and thrombomodulin (TM) is essential to the formation of activated protein C (APC), one of the key factors regulating blood coagulation. In our study, we showed that resistin, an adipocyte hormone, suppresses thrombin-induced protein C activation in endothelial cells. Resistin treatment results in a reduction in EPCR expression, but not TM. Mechanistically, we demonstrate that resistin induces expression of the nuclear transcription factor SP-1, which could lead to downregulation of EPCR. Both inhibition and silencing of SP1 protein abolishes abnormal APC generation induced by resistin. Collectively, our data support a new role of resistin in disturbing APC formation.
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Base de dados:
MEDLINE
Assunto principal:
Proteína C
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Fator de Transcrição Sp1
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Resistina
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Células Endoteliais da Veia Umbilical Humana
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Receptor de Proteína C Endotelial
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article