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Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease.
Hu, Jinhui; Pan, Tingting; An, Baijiao; Li, Zhengcunxiao; Li, Xingshu; Huang, Ling.
Afiliação
  • Hu J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Pan T; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • An B; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Li Z; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Li X; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: lixsh@mail.sysu.edu.cn.
  • Huang L; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: huangl72@mail.sysu.edu.cn.
Eur J Med Chem ; 163: 512-526, 2019 Feb 01.
Article em En | MEDLINE | ID: mdl-30553143
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidas / Desenho de Fármacos / Clioquinol / Rolipram / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Doença de Alzheimer / Aminopiridinas Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidas / Desenho de Fármacos / Clioquinol / Rolipram / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Doença de Alzheimer / Aminopiridinas Idioma: En Ano de publicação: 2019 Tipo de documento: Article