Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens.
Bioorg Med Chem Lett
; 29(2): 134-137, 2019 01 15.
Article
em En
| MEDLINE
| ID: mdl-30553734
ABSTRACT
Two new cassaine-type diterpenoids, namely erythrofordins D (1) and E (2), sourced from a Cameroon collection of Erythrophleum suaveolens were isolated and assessed for anti-tumor activity. In the NCI-60 cancer cell assay, erythrofordins D (1) and E (2) were found to be cytotoxic in the low micro molar ranges with a mean GI50 value of 2.45 and 0.71⯵M, mean TGI value of 9.77 and 2.29⯵M, and a mean LC50 of 26.92 and 11.48⯵M for 1 and 2 respectively. Using the COMPARE algorithm, the new compounds were found to have similar NCI-60 response profiles to the known cardiac glycosides hyrcanoside and strophanthin. In addition, in an assay examining the viability and contractile function in human cardiomyocytes derived from induced pluripotent stem-cells, erythrofordins showed cardiotoxicity effects at concentrations as low as 0.03⯵g/mL.
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Base de dados:
MEDLINE
Assunto principal:
Caesalpinia
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Miócitos Cardíacos
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Diterpenos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article