The influence of high-dose intraoperative remifentanil on postoperative sore throat: a prospective randomized study: A CONSORT compliant article.
Medicine (Baltimore)
; 97(50): e13510, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-30558006
ABSTRACT
BACKGROUND:
Endotracheal intubation for general anesthesia causes postoperative sore throat (POST). This study is designed to evaluate the effect of high-dose remifentanil on the incidence of POST in patients after general anesthesia.METHODS:
Ninety-two patients scheduled for orthopedic lower extremity surgery under general anesthesia were randomly assigned into 1 of 2 groups. In the high-dose remifentanil (HR) group (nâ=â46), remifentanil was infused at a rate of 0.25âµg/kg/min and subsequently increased or decreased by 0.05âµg/kg/min per clinical demand. In the low-dose remifentanil (LR) group (nâ=â46), remifentanil was infused at a rate of 0.05âµg/kg/min. The incidence of POST was monitored at 0, 2, 4, and 24 hours postoperatively. Complications regarding opioids were compared between groups.RESULTS:
The overall incidence of POST was higher in the HR group compared with that in the LR group [33 (72%) vs 18 (39%), Pâ=â.022]. The incidence of POST at 0, 2, and 24âhours after surgery was higher in the HR group compared with that in the LR group (Pâ<â.001, Pâ=â.001, and Pâ=â.001, respectively). The incidence of postoperative nausea, vomiting, drowsiness, and headache was similar between the groups. The incidence of postoperative shivering was higher in the HR group than in the LR group [10 (22%) vs 2 (4%), difference 17%, 95% CI 2%-33%, Pâ=â.027].CONCLUSION:
A relatively large dose of intraoperative remifentanil increased the incidence of POST in patients for orthopedic surgery under general anesthesia. TRIAL REGISTRATION Clinicaltrials.gov Identifier NCT03173339.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Faringite
/
Remifentanil
/
Analgésicos Opioides
/
Cuidados Intraoperatórios
/
Intubação Intratraqueal
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article