Effects of porcine brain hydrolysate on impairment of cognitive learning ability in amyloid ß(1-40) -infused rats.
Anim Sci J
; 90(2): 271-279, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30565354
ABSTRACT
This study assessed whether administering porcine brain hydrolysate (PBH) ameliorates the impairment of spatial cognition learning ability in amyloid ß (Aß)-infused rats. PBH was prepared using organic solvents (i.e., acetone and ethanol). Enzyme hydrolysates were derived from these PBH and the sequence of the Aß peptide for infusion was selected. The results indicated the PBH, in particular EP (porcine brain extract with ethanol and protease N), demonstrated the potentials to reduce damage of neurodegenerative disorders in vitro and in vivo. The principal findings of this study indicate that PBH has prolyl endopeptidase inhibitory activity in vitro. Moreover, administering EP to Aß(1-40)-infused rats significantly improves their performance on reference, spatial performance, and working memory tests during water maze tasks; concurrent proportional decreases are also observed in malondialdehyde levels, acetylcholinesterase (AChE) activity, and Aß accumulation levels in brain tissues. The PBH was suggested to ameliorate learning deficits associated with Alzheimer's disease by inhibition of lipid peroxidation in the brain of Aß infused rat.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Extratos de Tecidos
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Encéfalo
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Química Encefálica
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Peptídeos beta-Amiloides
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Aprendizagem em Labirinto
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Aprendizagem Espacial
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Deficiências da Aprendizagem
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Memória de Curto Prazo
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article