Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity.
Chem Commun (Camb)
; 55(5): 711-714, 2019 Jan 10.
Article
em En
| MEDLINE
| ID: mdl-30566122
ABSTRACT
Mincle, expressed in activated phagocytes, recognizes the lipid ligand to activate the innate immune system. We have synthesized glycerol derivatives possessing simple alkyl chains or aromatic rings and elucidated their structure-activity relationships using a Mincle-mediated signaling assay. The activity depends on the length of the simple acyl chains of the glycerol derivatives.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
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Transdução de Sinais
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Lectinas Tipo C
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Monoglicerídeos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article