Mutant p63 Affects Epidermal Cell Identity through Rewiring the Enhancer Landscape.

Qu, Jieqiong; Tanis, Sabine E J; Smits, Jos P H; Kouwenhoven, Evelyn N; Oti, Martin; van den Bogaard, Ellen H; Logie, Colin; Stunnenberg, Hendrik G; van Bokhoven, Hans; Mulder, Klaas W; Zhou, Huiqing

Qu, Jieqiong; Tanis, Sabine E J; Smits, Jos P H; Kouwenhoven, Evelyn N; Oti, Martin; van den Bogaard, Ellen H; Logie, Colin; Stunnenberg, Hendrik G; van Bokhoven, Hans; Mulder, Klaas W; Zhou, Huiqing.

Afiliação

Qu J; Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands.
Tanis SEJ; Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands.
Smits JPH; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Kouwenhoven EN; Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands.
Oti M; Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands.
van den Bogaard EH; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Logie C; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands.
Stunnenberg HG; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands.
van Bokhoven H; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Cognitive Neurosciences, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Mulder KW; Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands.
Zhou H; Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: jo.zhou@radboudumc.nl.

Cell Rep ; 25(12): 3490-3503.e4, 2018 12 18.

Article em En | MEDLINE | ID: mdl-30566872

Assuntos

Elementos Facilitadores Genéticos/genética; Células Epidérmicas/citologia; Células Epidérmicas/metabolismo; Mutação/genética; Fatores de Transcrição/genética; Proteínas Supressoras de Tumor/genética; Sequência de Aminoácidos; Diferenciação Celular/genética; Cromatina/metabolismo; Subunidade alfa 2 de Fator de Ligação ao Core/genética; Subunidade alfa 2 de Fator de Ligação ao Core/metabolismo; Regulação da Expressão Gênica; Humanos; Queratinócitos/citologia; Queratinócitos/metabolismo; Modelos Biológicos; Ligação Proteica; Fatores de Transcrição/química; Fatores de Transcrição/metabolismo; Transcrição Gênica; Transcriptoma/genética; Proteínas Supressoras de Tumor/química; Proteínas Supressoras de Tumor/metabolismo

Palavras-chave

EEC syndrome; cell identity; enhancer; epidermal keratinocytes; p63; transcriptional regulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Elementos Facilitadores Genéticos / Proteínas Supressoras de Tumor / Células Epidérmicas / Mutação Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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