The Wnt modulator ICG001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR150/CD44 axis.
Int J Oncol
; 54(3): 1010-1020, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30569106
ABSTRACT
The Wnt signaling pathway is known to serve an important role in the control of cell migration. The present study analyzed the mechanisms underlying the in vitro modulation of the migration of nasopharyngeal carcinoma (NPC) cells by the CREBbinding protein/catenin antagonist and Wnt modulator ICG001. The results revealed that ICG001mediated inhibition of tumor cell migration involved downregulated mRNA and protein expression of the Wnt target gene cluster of differentiation (CD)44. It was also demonstrated that ICG001 downregulated the expression of CD44, and this effect was accompanied by restored expression of microRNA (miRNA)150 in various NPC cell lines. Using a CD44 3'untranslated region luciferase reporter assay, miR150 was confirmed to be a novel CD44targeting miRNA, which could directly target CD44 and subsequently regulate the migration of NPC cells. The present study provides further insight into the inhibition of tumor cell migration through the modulation of miRNA expression by the Wnt modulator ICG001.
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Base de dados:
MEDLINE
Assunto principal:
Pirimidinonas
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Movimento Celular
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Compostos Bicíclicos Heterocíclicos com Pontes
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Receptores de Hialuronatos
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MicroRNAs
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Via de Sinalização Wnt
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Carcinoma Nasofaríngeo
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article