MDSCs in infectious diseases: regulation, roles, and readjustment.
Cancer Immunol Immunother
; 68(4): 673-685, 2019 Apr.
Article
em En
| MEDLINE
| ID: mdl-30569204
ABSTRACT
Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Transmissíveis
/
Células Supressoras Mieloides
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article