Latent autoimmune diabetes of adulthood (LADA) is associated with small fibre neuropathy.
Diabet Med
; 36(9): 1118-1124, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-30575096
ABSTRACT
AIM:
To assess if latent autoimmune diabetes of adulthood (LADA) is associated with small fibre neuropathy.METHODS:
Participants with LADA (n=31), Type 2 diabetes (n=31) and healthy control participants without diabetes (n=31) underwent a detailed assessment of neurologic deficits, quantitative sensory testing, electrophysiology, skin biopsy and corneal confocal microscopy.RESULTS:
The groups were matched for age (healthy control without diabetes 53.5±9.1 vs. Type 2 diabetes 58.0±6.5 vs. LADA 53.2±11.6 years), duration of diabetes (Type 2 diabetes 10.0±8.3 vs. LADA 11.0±9.1 years) and blood pressure. However, BMI (P=0.01) and triglycerides (P=0.0008) were lower and HbA1c (P=0.0005), total cholesterol (P=0.01) and HDL (P=0.002) were higher in participants with LADA compared with Type 2 diabetes. Peroneal motor nerve conduction velocity (P=0.04) and sural sensory nerve conduction velocity (P=0.008) were lower in participants with latent autoimmune diabetes in adults compared with Type 2 diabetes. Intra-epidermal nerve fibre density (P=0.008), corneal nerve fibre density (P=0.003) and corneal nerve branch density (P=0.006) were significantly lower in participants with LADA compared with Type 2 diabetes. There were no significant differences in the other neuropathy parameters.CONCLUSIONS:
Despite comparable age and duration of diabetes, participants with LADA demonstrate more severe neuropathy and particularly small fibre neuropathy, compared with participants with Type 2 diabetes.
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Base de dados:
MEDLINE
Assunto principal:
Neuropatia de Pequenas Fibras
/
Diabetes Autoimune Latente em Adultos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article