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Successful Heart Transplantation After Desensitization in a Patient With Extremely High Panel-Reactive Antibody Levels and Pretransplant Donor-Specific Antibody: A Case Report.
Nakamura, Y; Yoshioka, D; Miyagawa, S; Yoshikawa, Y; Hata, H; Matsuura, R; Toda, K; Sawa, Y.
Afiliação
  • Nakamura Y; Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Yoshioka D; Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Miyagawa S; Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Yoshikawa Y; Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Hata H; Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Matsuura R; Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Toda K; Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Sawa Y; Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan. Electronic address: sawa-p@surg1.med.osaka-u.ac.jp.
Transplant Proc ; 50(10): 4067-4070, 2018 Dec.
Article em En | MEDLINE | ID: mdl-30577317
Elevated panel-reactive antibody (PRA) levels serve as a significant risk factor for allograft survival and episodes of rejection after heart transplantation (HTX). Patients with high PRA levels tend to show expressions of donor-specific human leukocyte antigen antibodies (DSA), which can cause catastrophic hyperacute rejection after HTX. Therefore, such highly sensitized patients are required to undergo strategic perioperative desensitization therapy. We describe a successful HTX after desensitization in a patient with extremely high PRA levels and pretransplant DSA positivity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dessensibilização Imunológica / Transplante de Coração / Antígenos HLA Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dessensibilização Imunológica / Transplante de Coração / Antígenos HLA Idioma: En Ano de publicação: 2018 Tipo de documento: Article