Pin1 inhibition reverses the acquired resistance of human hepatocellular carcinoma cells to Regorafenib via the Gli1/Snail/E-cadherin pathway.

Wang, Jichuang; Zhang, Nan; Han, Qi; Lu, Wenxian; Wang, Long; Yang, Dayun; Zheng, Min; Zhang, Zhenzhen; Liu, Hekun; Lee, Tae Ho; Zhou, Xiao Zhen; Lu, Kun Ping

Wang, Jichuang; Zhang, Nan; Han, Qi; Lu, Wenxian; Wang, Long; Yang, Dayun; Zheng, Min; Zhang, Zhenzhen; Liu, Hekun; Lee, Tae Ho; Zhou, Xiao Zhen; Lu, Kun Ping.

Afiliação

Wang J; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Zhang N; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Han Q; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Lu W; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Wang L; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Yang D; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Zheng M; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Zhang Z; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Liu H; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Lee TH; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, China.
Zhou XZ; Division of Translational Therapeutics, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Lu KP; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, China; Division of Translational Therapeutics, Department of Medicine and Cancer R

Cancer Lett ; 444: 82-93, 2019 03 01.

Article em En | MEDLINE | ID: mdl-30583078

Assuntos

Antígenos CD/metabolismo; Caderinas/metabolismo; Carcinoma Hepatocelular/tratamento farmacológico; Resistencia a Medicamentos Antineoplásicos; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Peptidilprolil Isomerase de Interação com NIMA/metabolismo; Compostos de Fenilureia/farmacologia; Piridinas/farmacologia; Fatores de Transcrição da Família Snail/metabolismo; Proteína GLI1 em Dedos de Zinco/metabolismo; Animais; Antígenos CD/genética; Apoptose; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Caderinas/genética; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Movimento Celular; Proliferação de Células; Humanos; Neoplasias Hepáticas/tratamento farmacológico; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Masculino; Camundongos; Camundongos Nus; Peptidilprolil Isomerase de Interação com NIMA/genética; Fatores de Transcrição da Família Snail/genética; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto; Proteína GLI1 em Dedos de Zinco/genética

Palavras-chave

EMT; HCC; Metastasis; Pin1; Regorafenib resistance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Piridinas / Antígenos CD / Caderinas / Regulação Neoplásica da Expressão Gênica / Carcinoma Hepatocelular / Resistencia a Medicamentos Antineoplásicos / Peptidilprolil Isomerase de Interação com NIMA / Proteína GLI1 em Dedos de Zinco / Fatores de Transcrição da Família Snail Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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