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Lead generation and optimization of novel GPR119 agonists with a spirocyclic cyclohexane structure.
Harada, Kazuhito; Mizukami, Jun; Watanabe, Takashi; Mori, Genki; Ubukata, Minoru; Suwa, Katsunori; Fukuda, Sumiaki; Negoro, Tamotsu; Sato, Motohide; Inaba, Takashi.
Afiliação
  • Harada K; Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan. Electronic address: kazuhito.harada@jt.com.
  • Mizukami J; Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
  • Watanabe T; Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
  • Mori G; Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
  • Ubukata M; Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
  • Suwa K; Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
  • Fukuda S; Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
  • Negoro T; Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
  • Sato M; Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
  • Inaba T; Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Bioorg Med Chem Lett ; 29(3): 373-379, 2019 02 01.
Article em En | MEDLINE | ID: mdl-30587450
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Cicloexanos / Receptores Acoplados a Proteínas G / Inibidores das Enzimas do Citocromo P-450 / Hipoglicemiantes Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Cicloexanos / Receptores Acoplados a Proteínas G / Inibidores das Enzimas do Citocromo P-450 / Hipoglicemiantes Idioma: En Ano de publicação: 2019 Tipo de documento: Article