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Targeted discovery and identification of novel nucleoside biomarkers in Apostichopus japonicus viscera using metabonomics.
Zhang, Xuan-Ming; Han, Li-Wen; Zhang, Shan-Shan; Li, Xiao-Bin; He, Qiu-Xia; Han, Jian; Wang, Xi-Min; Liu, Ke-Chun.
Afiliação
  • Zhang XM; a Key Laboratory for Drug Screening Technology, Biology Institute , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , Shandong , P.R. China.
  • Han LW; a Key Laboratory for Drug Screening Technology, Biology Institute , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , Shandong , P.R. China.
  • Zhang SS; a Key Laboratory for Drug Screening Technology, Biology Institute , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , Shandong , P.R. China.
  • Li XB; a Key Laboratory for Drug Screening Technology, Biology Institute , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , Shandong , P.R. China.
  • He QX; a Key Laboratory for Drug Screening Technology, Biology Institute , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , Shandong , P.R. China.
  • Han J; a Key Laboratory for Drug Screening Technology, Biology Institute , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , Shandong , P.R. China.
  • Wang XM; a Key Laboratory for Drug Screening Technology, Biology Institute , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , Shandong , P.R. China.
  • Liu KC; a Key Laboratory for Drug Screening Technology, Biology Institute , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , Shandong , P.R. China.
Nucleosides Nucleotides Nucleic Acids ; 38(3): 203-217, 2019.
Article em En | MEDLINE | ID: mdl-30588871
ABSTRACT
In this study, we investigated the metabonomic profiles of Apostichopus japonicus using an LC-MS-based method in conjunction with multivariate data analysis. Based on the PLS-DA model, 85 differential metabolites (VIP value >1.0) were obtained from viscera and body wall samples. The MS/MS and NMR experiments were used for the qualitative identification of the characteristic peaks. Sphingoid-based nucleoside analogues were the main components in Chinese A. japonicus viscera. Our findings demonstrate that A. japonicus viscera contain a large number of compounds that may have applications as nutraceuticals or pharmaceuticals.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vísceras / Biomarcadores / Stichopus / Metabolômica / Nucleosídeos Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vísceras / Biomarcadores / Stichopus / Metabolômica / Nucleosídeos Idioma: En Ano de publicação: 2019 Tipo de documento: Article