A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain.

Ivanov, Ivan; Matafonov, Anton; Sun, Mao-Fu; Mohammed, Bassem M; Cheng, Qiufang; Dickeson, S Kent; Kundu, Suman; Verhamme, Ingrid M; Gruber, Andras; McCrae, Keith; Gailani, David

Ivanov, Ivan; Matafonov, Anton; Sun, Mao-Fu; Mohammed, Bassem M; Cheng, Qiufang; Dickeson, S Kent; Kundu, Suman; Verhamme, Ingrid M; Gruber, Andras; McCrae, Keith; Gailani, David.

Afiliação

Ivanov I; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Matafonov A; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Sun MF; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Mohammed BM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Cheng Q; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Dickeson SK; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Kundu S; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland OH.
Verhamme IM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Gruber A; Department of Biomedical Engineering, School of Medicine, Oregon Health & Sciences University, Portland, OR.
McCrae K; Aronora, Inc, Portland, OR.
Gailani D; Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH; and.

Blood ; 133(10): 1152-1163, 2019 03 07.

Article em En | MEDLINE | ID: mdl-30591525

Assuntos

Fator XII/química; Fator XIa/química; Angioedema Hereditário Tipo III/sangue; Angioedema Hereditário Tipo III/genética; Angioedemas Hereditários; Animais; Arginina/química; Coagulação Sanguínea; Bradicinina/sangue; Catálise; Proteína Inibidora do Complemento C1/química; Fator XIIa/química; Células HEK293; Humanos; Cininogênios/sangue; Lisina/química; Camundongos; Camundongos Endogâmicos C57BL; Calicreína Plasmática/química; Pré-Calicreína/química; Ligação Proteica; Proteínas Recombinantes/química; Propriedades de Superfície; Trombina/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator XII / Fator XIa / Angioedema Hereditário Tipo III Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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