Beyond sequence variation: assessment of copy number variation in adult glioblastoma through targeted tumor somatic profiling.

McNulty, Samantha N; Cottrell, Catherine E; Vigh-Conrad, Katinka A; Carter, Jamal H; Heusel, Jonathan W; Ansstas, George; Dahiya, Sonika

McNulty, Samantha N; Cottrell, Catherine E; Vigh-Conrad, Katinka A; Carter, Jamal H; Heusel, Jonathan W; Ansstas, George; Dahiya, Sonika.

Afiliação

McNulty SN; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110. Electronic address: smcnulty@wustl.edu.
Cottrell CE; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43205. Electronic address: Catherine.Cottrell@nationwidechildrens.org.
Vigh-Conrad KA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110. Electronic address: kconrad@wustl.edu.
Carter JH; Department of Transfusion Medicine, Clinical Center, National Institute of Health, Bethesda, MD 20892. Electronic address: jamal.carter@nih.gov.
Heusel JW; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110; Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110. Electronic address: heuselj@wustl.edu.
Ansstas G; Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110. Electronic address: gansstas@wustl.edu.
Dahiya S; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110. Electronic address: sdahiya@wustl.edu.

Hum Pathol ; 86: 170-181, 2019 04.

Article em En | MEDLINE | ID: mdl-30594748

Assuntos

Neoplasias Encefálicas/genética; Variações do Número de Cópias de DNA; Glioblastoma/genética; Mutação; Adulto; Idoso; Idoso de 80 Anos ou mais; Neoplasias Encefálicas/patologia; Receptores ErbB/genética; Feminino; Amplificação de Genes; Regulação Neoplásica da Expressão Gênica; Glioblastoma/patologia; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Masculino; Pessoa de Meia-Idade; Prognóstico

Palavras-chave

Clinical sequencing; Copy number variation; EGFR amplification; Glioblastoma; Next-generation sequencing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma / Variações do Número de Cópias de DNA / Mutação Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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