Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter.

Kajimoto, Taketoshi; Caliman, Alisha D; Tobias, Irene S; Okada, Taro; Pilo, Caila A; Van, An-Angela N; Andrew McCammon, J; Nakamura, Shun-Ichi; Newton, Alexandra C

Kajimoto, Taketoshi; Caliman, Alisha D; Tobias, Irene S; Okada, Taro; Pilo, Caila A; Van, An-Angela N; Andrew McCammon, J; Nakamura, Shun-Ichi; Newton, Alexandra C.

Afiliação

Kajimoto T; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA. anewton@ucsd.edu tkajimot@med.kobe-u.ac.jp.
Caliman AD; Division of Biochemistry, Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.
Tobias IS; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.
Okada T; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.
Pilo CA; Division of Biochemistry, Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.
Van AN; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.
Andrew McCammon J; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.
Nakamura SI; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92037, USA.
Newton AC; Division of Biochemistry, Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.

Sci Signal ; 12(562)2019 01 01.

Article em En | MEDLINE | ID: mdl-30600259

Assuntos

Proteínas Luminescentes/metabolismo; Lisofosfolipídeos/metabolismo; Proteína Quinase C/metabolismo; Transdução de Sinais; Esfingosina/análogos & derivados; Animais; Apoptose; Células COS; Linhagem Celular Tumoral; Chlorocebus aethiops; Ativação Enzimática; Células HeLa; Células Hep G2; Humanos; Isoenzimas/genética; Isoenzimas/metabolismo; Proteínas Luminescentes/genética; Células MCF-7; Microscopia de Fluorescência; Simulação de Acoplamento Molecular; Ligação Proteica; Proteína Quinase C/genética; Esfingosina/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esfingosina / Proteína Quinase C / Lisofosfolipídeos / Transdução de Sinais / Proteínas Luminescentes Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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