Plasmodium Para-Aminobenzoate Synthesis and Salvage Resolve Avoidance of Folate Competition and Adaptation to Host Diet.

Matz, Joachim Michael; Watanabe, Mutsumi; Falade, Mofolusho; Tohge, Takayuki; Hoefgen, Rainer; Matuschewski, Kai

Matz, Joachim Michael; Watanabe, Mutsumi; Falade, Mofolusho; Tohge, Takayuki; Hoefgen, Rainer; Matuschewski, Kai.

Afiliação

Matz JM; Department of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany; Parasitology Unit, Max Planck Institute of Infection Biology, 10117 Berlin, Germany. Electronic address: joachim.michael.matz@hu-berlin.de.
Watanabe M; Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany; Nara Institute of Science and Technology, Graduate School of Biological Sciences, Plant Secondary Metabolism, 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan.
Falade M; University of Kentucky College of Pharmacy, Lexington, KY, USA.
Tohge T; Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany; Nara Institute of Science and Technology, Graduate School of Biological Sciences, Plant Secondary Metabolism, 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan.
Hoefgen R; Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany.
Matuschewski K; Department of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany; Parasitology Unit, Max Planck Institute of Infection Biology, 10117 Berlin, Germany.

Cell Rep ; 26(2): 356-363.e4, 2019 01 08.

Article em En | MEDLINE | ID: mdl-30625318

Assuntos

Adaptação Fisiológica; Dieta; Ácido Fólico/metabolismo; Interações Hospedeiro-Parasita; Plasmodium/metabolismo; para-Aminobenzoatos/metabolismo; Animais; Feminino; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Oxo-Ácido-Liases/metabolismo; Plasmodium/patogenicidade; Proteínas de Protozoários/metabolismo; Transaminases/metabolismo

Palavras-chave

ADCL; ADCS; Plasmodium; aminodeoxychorismate lyase; aminodeoxychorismate synthase; folate; malaria; milk; pABA; para-aminobenzoic acid

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium / Adaptação Fisiológica / Dieta / Para-Aminobenzoatos / Ácido Fólico / Interações Hospedeiro-Parasita Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google