11-Step Total Synthesis of Teleocidins B-1-B-4.
J Am Chem Soc
; 141(4): 1494-1497, 2019 01 30.
Article
em En
| MEDLINE
| ID: mdl-30636411
ABSTRACT
A unified and modular approach to the teleocidin B family of natural products is presented that proceeds in 11 steps and features an array of interesting strategies and methods. Indolactam V, the known biosynthetic precursor to this family, was accessed through electrochemical amination, Cu-mediated aziridine opening, and a remarkable base-induced macrolactamization. Guided by a desire to minimize concession steps, the tactical combination of C-H borylation and a Sigman-Heck transform enabled the convergent, stereocontrolled synthesis of the teleocidins.
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1
Base de dados:
MEDLINE
Assunto principal:
Toxinas de Lyngbya
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article