CD3+CD20+ T cells and their roles in human diseases.
Hum Immunol
; 80(3): 191-194, 2019 Mar.
Article
em En
| MEDLINE
| ID: mdl-30639700
ABSTRACT
CD3+CD20+ T cells are a population of CD3+ T cells co-expressing CD20 that make up toâ¯â¼3-5% of the CD3+ T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3+CD20+ T cells are heterogeneous for containing a lower proportion of CD4+ cells, but produce higher levels of IL-17A and/or IFN-γ than those of CD3+CD20- T cells. Recently, emerging studies have shown a pathogenic behavior of CD3+CD20+ T cells in autoimmune diseases and CD20+ T-cell malignancies, and patients with the diseases may benefit from anti-CD20 immunotherapy to deplete these cells. However, CD3+CD20+ T cells may also play a protective role in ovarian cancer and HIV infection for their strong propensity to IFN-γ production. In this review, we will describe the current knowledge about CD3+CD20+ T-cell biology, and discuss their functional roles in autoimmune diseases as well as cancer and infectious diseases.
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Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos T
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Complexo CD3
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Antígenos CD20
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Suscetibilidade a Doenças
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article