Pharmacokinetics and pharmacodynamics of nitric oxide mimetic agents.
Nitric Oxide
; 84: 69-78, 2019 03 01.
Article
em En
| MEDLINE
| ID: mdl-30641123
ABSTRACT
Drug discovery focusing on NO mimetics has been hamstrung due to its unconventional nature. Central to these challenges is the fact that direct measurement of molecular NO in biological systems is exceedingly difficulty. Hence, drug development of NO mimetics must rely upon measurement of the NO donating specie (i.e., a prodrug) and a downstream marker of efficacy without directly measuring the molecule, NO, that is responsible for biological effect. The focus of this review is to catalog in vivo attempts to monitor the pharmacokinetics (PK) of the NO donating specie and the pharmacodynamic (PD) readout of NO bioactivity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doadores de Óxido Nítrico
/
Óxido Nítrico
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article