Your browser doesn't support javascript.
loading
Vascular dysfunction-The disregarded partner of Alzheimer's disease.
Sweeney, Melanie D; Montagne, Axel; Sagare, Abhay P; Nation, Daniel A; Schneider, Lon S; Chui, Helena C; Harrington, Michael G; Pa, Judy; Law, Meng; Wang, Danny J J; Jacobs, Russell E; Doubal, Fergus N; Ramirez, Joel; Black, Sandra E; Nedergaard, Maiken; Benveniste, Helene; Dichgans, Martin; Iadecola, Costantino; Love, Seth; Bath, Philip M; Markus, Hugh S; Al-Shahi Salman, Rustam; Allan, Stuart M; Quinn, Terence J; Kalaria, Rajesh N; Werring, David J; Carare, Roxana O; Touyz, Rhian M; Williams, Steve C R; Moskowitz, Michael A; Katusic, Zvonimir S; Lutz, Sarah E; Lazarov, Orly; Minshall, Richard D; Rehman, Jalees; Davis, Thomas P; Wellington, Cheryl L; González, Hector M; Yuan, Chun; Lockhart, Samuel N; Hughes, Timothy M; Chen, Christopher L H; Sachdev, Perminder; O'Brien, John T; Skoog, Ingmar; Pantoni, Leonardo; Gustafson, Deborah R; Biessels, Geert Jan; Wallin, Anders; Smith, Eric E.
Afiliação
  • Sweeney MD; Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Montagne A; Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Sagare AP; Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Nation DA; Department of Psychology, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
  • Schneider LS; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Psychiatry and the Behavioral Sciences, Keck School of
  • Chui HC; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Harrington MG; Huntington Medical Research Institutes, Pasadena, CA, USA.
  • Pa J; Laboratory of Neuro Imaging (LONI), Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Law M; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA; Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Wang DJJ; Laboratory of Neuro Imaging (LONI), Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Jacobs RE; Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Doubal FN; Neuroimaging Sciences and Brain Research Imaging Center, Division of Neuroimaging Sciences, Center for Clinical Brain Sciences, UK Dementia Research Institute at the University of Edinburgh, UK.
  • Ramirez J; LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Heart and Stroke Foundation Canadian Partnership for Stroke Re
  • Black SE; Department of Medicine (Neurology), Hurvitz Brain Sciences Program, Canadian Partnership for Stroke Recovery, and LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto Dementia Research Alliance, University of Toronto, Toronto, Canad
  • Nedergaard M; Section for Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY, USA.
  • Benveniste H; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
  • Dichgans M; Institute for Stroke and Dementia Research (ISD), Ludwing-Maximilians-University Munich, Munich, Germany.
  • Iadecola C; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
  • Love S; Institute of Clinical Neurosciences, University of Bristol, School of Medicine, Level 2 Learning and Research, Southmead Hospital, Bristol, UK.
  • Bath PM; Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital Campus, Nottingham, UK; Stroke, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, UK.
  • Markus HS; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
  • Al-Shahi Salman R; Neuroimaging Sciences and Brain Research Imaging Center, Division of Neuroimaging Sciences, Center for Clinical Brain Sciences, UK Dementia Research Institute at the University of Edinburgh, UK.
  • Allan SM; Faculty of Biology, Medicine and Health, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Manchester, UK.
  • Quinn TJ; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  • Kalaria RN; Neurovascular Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
  • Werring DJ; Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, UK.
  • Carare RO; Faculty of Medicine, University of Southampton, Southampton, UK.
  • Touyz RM; British Heart Foundation, Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
  • Williams SCR; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Moskowitz MA; Stroke and Neurovascular Regulation Laboratory, Departments of Radiology and Neurology Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
  • Katusic ZS; Department of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Lutz SE; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
  • Lazarov O; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
  • Minshall RD; Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA; Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA.
  • Rehman J; Department of Pharmacology, The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL, USA; Department of Medicine, The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL, USA.
  • Davis TP; Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
  • Wellington CL; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • González HM; Department of Neurosciences, University of California, San Diego, CA, USA.
  • Yuan C; Department of Radiology, University of Washington, Seattle, WA, USA.
  • Lockhart SN; Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; Alzheimer's Disease Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Hughes TM; Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; Alzheimer's Disease Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Chen CLH; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Memory Aging and Cognition Centre, National University Health System, Singapore; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Memory Aging and Co
  • Sachdev P; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Australia, Sydney, Australia.
  • O'Brien JT; Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Skoog I; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
  • Pantoni L; "L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
  • Gustafson DR; Department of Neurology, State University of New York-Downstate Medical Center, Brooklyn, NY, USA.
  • Biessels GJ; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Wallin A; Institute of Neuroscience and Physiology, University of Gothenburg, Gothenberg, Sweden.
  • Smith EE; Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.
Alzheimers Dement ; 15(1): 158-167, 2019 01.
Article em En | MEDLINE | ID: mdl-30642436
Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging-Alzheimer's Association describes a biomarker-based pathologic definition of AD focused on amyloid, tau, and neuronal injury. In response to this article, here we first discussed evidence that vascular dysfunction is an important early event in AD pathophysiology. Next, we examined various imaging sequences that could be easily implemented to evaluate different types of vascular dysfunction associated with, and/or contributing to, AD pathophysiology, including changes in blood-brain barrier integrity and cerebral blood flow. Vascular imaging biomarkers of small vessel disease of the brain, which is responsible for >50% of dementia worldwide, including AD, are already established, well characterized, and easy to recognize. We suggest that these vascular biomarkers should be incorporated into the AD Research Framework to gain a better understanding of AD pathophysiology and aid in treatment efforts.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Vasculares / Biomarcadores / Doença de Alzheimer / Substância Branca Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Vasculares / Biomarcadores / Doença de Alzheimer / Substância Branca Idioma: En Ano de publicação: 2019 Tipo de documento: Article