Chimeric vaccine strain of type O foot-and-mouth disease elicits a strong immune response in pigs against ME-SA and SEA topotypes.
Vet Microbiol
; 229: 124-129, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30642587
ABSTRACT
Foot-and-mouth disease (FMD) is an acute infectious disease occurring in cloven-hoofed animals. There are many variations of the virus, making it difficult to protect against the various strains with one virus vaccine. The immunogenicity has generally been evaluated in pigs using neutralizing antibodies to determine the protection level against foot-and-mouth disease virus type O. Therefore, the vaccine from the chimeric vaccine strain of ME-SA (VP4, VP2, and VP3) and SEA (VP1) topotypes developed in this study is expected to be able to protect with high neutralizing antibody titers against most of the eight FMD viruses of the four different topotypes (ME-SA, SEA, Cathay, and EURO-SA) of type O in pigs. This is a new technique for powerful vaccine development, with multiple preventive roles against various epidemic FMD strains.
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Base de dados:
MEDLINE
Assunto principal:
Vacinas Virais
/
Vírus da Febre Aftosa
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Febre Aftosa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article