Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata.
J Food Drug Anal
; 27(1): 111-117, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30648564
ABSTRACT
Seven new isoprenyl phenolic ethers, namely fimbriethers AâG (1â7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 µM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with Emax values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1â7 were not involved in the regulation of endothelial NOS-mediated NO production.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Xylariales
/
Isópteros
/
Éteres
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article