Polymer-coated superparamagnetic iron oxide nanoparticles as T<sub>2</sub> contrast agent for MRI and their uptake in liver.

Ali, Lamiaa Ma; Marzola, Pasquina; Nicolato, Elena; Fiorini, Silvia; Heras Guillamón, Marcelo de Las; Piñol, Rafael; Gabilondo, Lierni; Millán, Angel; Palacio, Fernando

Polymer-coated superparamagnetic iron oxide nanoparticles as T₂ contrast agent for MRI and their uptake in liver.

Ali, Lamiaa Ma; Marzola, Pasquina; Nicolato, Elena; Fiorini, Silvia; Heras Guillamón, Marcelo de Las; Piñol, Rafael; Gabilondo, Lierni; Millán, Angel; Palacio, Fernando.

Afiliação

Ali LM; Instituto de Ciencia de Materiales de Aragón, CSIC - Universidad de Zaragoza; & Departamento de Física de la Materia Condensada, Facultad de Ciencias, 50009 Zaragoza, Spain.
Marzola P; Instituto de Ciencia de Materiales de Aragón, CSIC - Universidad de Zaragoza; & Departamento de Física de la Materia Condensada, Facultad de Ciencias, 50009 Zaragoza, Spain.
Nicolato E; Department of Computer Science, Verona University, Verona, Italy.
Fiorini S; Department of Computer Science, Verona University, Verona, Italy.
Heras Guillamón ML; Department of Neurological & Movement Sciences, Verona University, Verona, Italy.
Piñol R; Department of Neurological & Movement Sciences, Verona University, Verona, Italy.
Gabilondo L; Department of Neurological & Movement Sciences, Verona University, Verona, Italy.
Millán A; Department of Neurological & Movement Sciences, Verona University, Verona, Italy.
Palacio F; Department of Animal Pathology, Unit of Histology & Anatomical Pathology, Zaragoza University, 50013 Zaragoza, Spain.

Future Sci OA ; 5(1): FSO235, 2019 Jan.

Article em En | MEDLINE | ID: mdl-30652014

ABSTRACT

ABSTRACT

AIM:

To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T2 magnetic resonance contrast agent and their uptake and toxicity in liver. MATERIALS &

METHODS:

Mice were intravenously injected with bioferrofluids and Endorem®. The magnetic resonance efficiency, uptake and in vivo toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques.

RESULTS:

Bioferrofluids are a good T2 contrast agent with a higher r2/r1 ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection.