[Antibiotic pharmacokinetics in patients with mucoviscidosis]. / Antibiotika-Pharmakokinetik bei Patienten mit Mukoviszidose.
Monatsschr Kinderheilkd
; 136(8): 475-8, 1988 Aug.
Article
em De
| MEDLINE
| ID: mdl-3065638
ABSTRACT
In this review we summarize the available literature on the pharmacokinetics of antibacterials in cystic fibrosis. A special impact is given on the results of our group which will be put in perspective with the results of other authors. The homogeneity of our patient population allows a valid comparison between patient and volunteer data. We do not confirm the previously suggested strongly enhanced elimination of antibacterials in CF. Our findings have recently been confirmed by other investigators. However, since in the clinical situation a more heterogeneous group of patients is treated it seems rational to increase the dose of the antibacterials by about 20-30%.
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Base de dados:
MEDLINE
Assunto principal:
Fibrose Cística
/
Antibacterianos
Idioma:
De
Ano de publicação:
1988
Tipo de documento:
Article