The Role of Tauroursodeoxycholic Acid on Dedifferentiation of Vascular Smooth Muscle Cells by Modulation of Endoplasmic Reticulum Stress and as an Oral Drug Inhibiting In-Stent Restenosis.

Luo, Hangqi; Zhou, Changzuan; Chi, Jufang; Pan, Sunlei; Lin, Hui; Gao, Feidan; Ni, Tingjuan; Meng, Liping; Zhang, Jie; Jiang, Chengjian; Ji, Zheng; Lv, Haitao; Guo, Hangyuan

Luo, Hangqi; Zhou, Changzuan; Chi, Jufang; Pan, Sunlei; Lin, Hui; Gao, Feidan; Ni, Tingjuan; Meng, Liping; Zhang, Jie; Jiang, Chengjian; Ji, Zheng; Lv, Haitao; Guo, Hangyuan.

Afiliação

Luo H; Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568 Zhongxing North Road, Shaoxing, Zhejiang, China.
Zhou C; Zhejiang University School of Medicine, Zhejiang, Hangzhou, China.
Chi J; Department of Cardiology, Wenzhou City Hospital of Traditional Chinese Medicine and Western Medicine Combined, Wenzhou, Zhejiang, China.
Pan S; Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568 Zhongxing North Road, Shaoxing, Zhejiang, China.
Lin H; Department of Cardiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Gao F; Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568 Zhongxing North Road, Shaoxing, Zhejiang, China.
Ni T; Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568 Zhongxing North Road, Shaoxing, Zhejiang, China.
Meng L; Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568 Zhongxing North Road, Shaoxing, Zhejiang, China.
Zhang J; Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568 Zhongxing North Road, Shaoxing, Zhejiang, China.
Jiang C; Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568 Zhongxing North Road, Shaoxing, Zhejiang, China.
Ji Z; Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568 Zhongxing North Road, Shaoxing, Zhejiang, China.
Lv H; Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568 Zhongxing North Road, Shaoxing, Zhejiang, China.
Guo H; Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568 Zhongxing North Road, Shaoxing, Zhejiang, China.

Cardiovasc Drugs Ther ; 33(1): 25-33, 2019 02.

Article em En | MEDLINE | ID: mdl-30663009

Assuntos

Doenças das Artérias Carótidas/cirurgia; Desdiferenciação Celular/efeitos dos fármacos; Stents Farmacológicos; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Procedimentos Endovasculares/instrumentação; Músculo Liso Vascular/efeitos dos fármacos; Miócitos de Músculo Liso/efeitos dos fármacos; Ácido Tauroquenodesoxicólico/farmacologia; Administração Oral; Animais; Aorta Torácica/efeitos dos fármacos; Aorta Torácica/metabolismo; Aorta Torácica/patologia; Artérias Carótidas/efeitos dos fármacos; Artérias Carótidas/metabolismo; Artérias Carótidas/patologia; Doenças das Artérias Carótidas/metabolismo; Doenças das Artérias Carótidas/patologia; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Modelos Animais de Doenças; Procedimentos Endovasculares/efeitos adversos; Fator 4 Semelhante a Kruppel; Masculino; Proteínas de Membrana/metabolismo; Músculo Liso Vascular/metabolismo; Músculo Liso Vascular/patologia; Miócitos de Músculo Liso/metabolismo; Miócitos de Músculo Liso/patologia; Neointima; Proteínas Serina-Treonina Quinases/metabolismo; Coelhos; Ratos Sprague-Dawley; Recidiva; Transdução de Sinais/efeitos dos fármacos; Ácido Tauroquenodesoxicólico/administração & dosagem; Proteína 1 de Ligação a X-Box/metabolismo

Palavras-chave

Dedifferentiation; Endoplasmic reticulum stress; IRE1/XBP1 signaling pathway; In-stent restenosis; Tauroursodeoxycholic acid; Vascular smooth muscle cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Tauroquenodesoxicólico / Doenças das Artérias Carótidas / Miócitos de Músculo Liso / Stents Farmacológicos / Desdiferenciação Celular / Procedimentos Endovasculares / Estresse do Retículo Endoplasmático / Músculo Liso Vascular Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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