A scrutiny of circulating microRNA biomarkers for drug-induced tubular and glomerular injury in rats.

Kagawa, Takumi; Zárybnický, Tomás; Omi, Takanao; Shirai, Yuji; Toyokuni, Shinya; Oda, Shingo; Yokoi, Tsuyoshi

Kagawa, Takumi; Zárybnický, Tomás; Omi, Takanao; Shirai, Yuji; Toyokuni, Shinya; Oda, Shingo; Yokoi, Tsuyoshi.

Afiliação

Kagawa T; Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagaya 466-8550, Japan.
Zárybnický T; Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagaya 466-8550, Japan.
Omi T; Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagaya 466-8550, Japan.
Shirai Y; Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagaya 466-8550, Japan.
Toyokuni S; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagaya 466-8550, Japan.
Oda S; Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagaya 466-8550, Japan.
Yokoi T; Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagaya 466-8550, Japan. Electronic address: tyokoi@med.nagoya-u.ac.jp.

Toxicology ; 415: 26-36, 2019 03 01.

Article em En | MEDLINE | ID: mdl-30682439

Assuntos

Cisplatino/toxicidade; Doxorrubicina/toxicidade; Gentamicinas/toxicidade; Glomérulos Renais/efeitos dos fármacos; Túbulos Renais/efeitos dos fármacos; MicroRNAs/sangue; Puromicina/toxicidade; Animais; Biomarcadores/sangue; Nitrogênio da Ureia Sanguínea; Creatinina/sangue; Regulação para Baixo/efeitos dos fármacos; Glomérulos Renais/lesões; Glomérulos Renais/patologia; Túbulos Renais/lesões; Túbulos Renais/patologia; Masculino; MicroRNAs/genética; Ratos; Ratos Sprague-Dawley; Reprodutibilidade dos Testes; Regulação para Cima/efeitos dos fármacos

Palavras-chave

Drug-induced acute kidney injury; Glomerular injury; Liquid biopsy; Tubular injury; miRNA sequencing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gentamicinas / Puromicina / Doxorrubicina / Cisplatino / MicroRNAs / Glomérulos Renais / Túbulos Renais Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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