Medicinal chemistry of metal chelating fragments in metalloenzyme active sites: A perspective.

Jiang, Zhensheng; You, Qidong; Zhang, Xiaojin

Jiang, Zhensheng; You, Qidong; Zhang, Xiaojin.

Afiliação

Jiang Z; Sate Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
You Q; Sate Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: youqd@163.com.
Zhang X; Sate Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Chemistry, School of Science, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: zxj@cpu.edu.cn.

Eur J Med Chem ; 165: 172-197, 2019 Mar 01.

Article em En | MEDLINE | ID: mdl-30684796

Assuntos

Quelantes/uso terapêutico; Química Farmacêutica/métodos; Metaloproteínas/antagonistas & inibidores; Animais; Domínio Catalítico; Desenho de Fármacos; Humanos

Palavras-chave

Geometrical parameter; Metal binding group; Metal chelation; Target-based drug design

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quelantes / Química Farmacêutica / Metaloproteínas Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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