Seroprevalence of varicella-zoster virus among pregnant women in Fayoum Governorate, Egypt.
J Egypt Public Health Assoc
; 94(1): 2, 2019.
Article
em En
| MEDLINE
| ID: mdl-30686830
ABSTRACT
BACKGROUND:
Chickenpox infection acquired during pregnancy is a serious condition. There may be congenital malformations and neonatal varicella syndrome with significant morbidity and mortality. Egypt has no routine varicella-zoster vaccination program.OBJECTIVE:
To assess the immune status against varicella-zoster virus (VZV) antibodies among a group of pregnant women and to study the relationship between VZV seroprevalence and some sociodemographic characteristics. SUBJECTS ANDMETHODS:
A descriptive cross-sectional study was conducted on a group of pregnant women (n = 333) attending antenatal care (ANC) clinic at Fayoum University Hospital. Serologic testing for VZV was performed using ELISA through the years 2016-2017.RESULTS:
VZV seroprevalence was detected in 294 (88.3%) of the 333 recruited pregnant women. Older age > 25 years old was significantly associated with low percent of VZV-negative antibodies (6.7% in versus 17.4% in younger age, OR (95%CI) 0.34 (0.17-0.70)), also having more than one child was significantly associated with a low percent of VZV-negative antibodies (8.2% versus 16.1% among participants with no children or having one child, OR 0.34 (0.17-0.70)).CONCLUSIONS:
Despite the absence of a routine VZV vaccination program in Egypt, VZV immunity was high among pregnant women, but less than that reported in many developed countries. We recommend targeted vaccination for women in the reproductive age especially young and primipara. TRIAL REGISTRATION Ethical Committee Registration number R67 session 42 date 12/11/2017(retrospectively registered).Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cuidado Pré-Natal
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Varicela
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Herpesvirus Humano 3
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Gestantes
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Anticorpos Antivirais
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article