3-Mercapto-5H-1,2,4-Triazino[5,6-b]Indole-5-Acetic Acid (Cemtirestat) Alleviates Symptoms of Peripheral Diabetic Neuropathy in Zucker Diabetic Fatty (ZDF) Rats: A Role of Aldose Reductase.

Soltesova Prnova, Marta; Svik, Karol; Bezek, Stefan; Kovacikova, Lucia; Karasu, Cimen; Stefek, Milan

Soltesova Prnova, Marta; Svik, Karol; Bezek, Stefan; Kovacikova, Lucia; Karasu, Cimen; Stefek, Milan.

Afiliação

Soltesova Prnova M; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 84104, Bratislava, Slovakia.
Svik K; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 84104, Bratislava, Slovakia.
Bezek S; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 84104, Bratislava, Slovakia.
Kovacikova L; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 84104, Bratislava, Slovakia.
Karasu C; Department of Medical Pharmacology, Faculty of Medicine, Gazi University, 06510, Besevler, Ankara, Turkey.
Stefek M; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 84104, Bratislava, Slovakia. Milan.Stefek@savba.sk.

Neurochem Res ; 44(5): 1056-1064, 2019 May.

Article em En | MEDLINE | ID: mdl-30689163

Assuntos

Aldeído Redutase/farmacologia; Neuropatias Diabéticas/tratamento farmacológico; Condução Nervosa/efeitos dos fármacos; Nervo Isquiático/efeitos dos fármacos; Aldeído Redutase/efeitos dos fármacos; Animais; Glicemia/efeitos dos fármacos; Glicemia/metabolismo; Neuropatias Diabéticas/metabolismo; Inibidores Enzimáticos/farmacologia; Hiperalgesia/tratamento farmacológico; Hiperalgesia/metabolismo; Ratos Zucker

Palavras-chave

Aldose reductase inhibitor; Cemtirestat; Diabetic peripheral neuropathy; Oxidative stress; Zucker diabetic fatty rats

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nervo Isquiático / Aldeído Redutase / Neuropatias Diabéticas / Condução Nervosa Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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