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Psychosocial Assessment of Candidates for Transplant (PACT) as a tool for psychological and social evaluation of allogeneic hematopoietic cell transplantation recipients.
Hong, Sanghee; Rybicki, Lisa; Corrigan, Donna; Dabney, Jane; Hamilton, Betty K; Kalaycio, Matt; Lawrence, Christine; McLellan, Linda; Sobecks, Ronald; Lee, Stephanie J; Majhail, Navneet S.
Afiliação
  • Hong S; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. sangheesanghee@gmail.com.
  • Rybicki L; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
  • Corrigan D; Blood & Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Dabney J; Blood & Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Hamilton BK; Blood & Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Kalaycio M; Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH, USA.
  • Lawrence C; Blood & Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • McLellan L; Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH, USA.
  • Sobecks R; Blood & Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Lee SJ; Blood & Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Majhail NS; Blood & Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Bone Marrow Transplant ; 54(9): 1443-1452, 2019 09.
Article em En | MEDLINE | ID: mdl-30696998
Psychosocial Assessment of Candidates for Transplant (PACT) is a tool originally developed to address psychosocial risks in solid organ transplant recipients and has the potential for application to hematopoietic cell transplantation (HCT) recipients. In a retrospective cohort study, we reviewed 404 adult allogeneic HCT cases from 2003 to 2014 to identify predictors of adverse psychosocial status as determined by PACT. Final PACT rating was poor/borderline (score 0-1) in 5%, acceptable (score 2) in 22%, good (score 3) in 44%, and excellent (score 4) in 29% recipients. In multivariable regression, higher PACT score was associated with White race (odds ratio [OR] 2.95, P < 0.001), having a related donor (OR 1.61, P = 0.015), and a higher quality of life score (OR 1.22/ 10-point increase in FACT-BMT total score, P < 0.001). PACT score correlated with all quality of life subscales. The final PACT score was associated with non-relapse mortality (HR 0.82/ 1-point increase, p = 0.03) in multivariable analysis that considered patient and disease factors, but not in models that also included transplant-related factors and performance status. PACT score was not associated with overall survival. PACT can be considered as part of a comprehensive psychosocial assessment for identifying patients who may require additional resources around allogeneic HCT.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Valor Preditivo dos Testes / Transplante de Células-Tronco Hematopoéticas Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Valor Preditivo dos Testes / Transplante de Células-Tronco Hematopoéticas Idioma: En Ano de publicação: 2019 Tipo de documento: Article