Application of bacterial therapeutic vaccine Immunovac-VP4 in the treatment of pollinosis.
Ter Arkh
; 90(3): 16-20, 2018 Apr 19.
Article
em En
| MEDLINE
| ID: mdl-30701850
ABSTRACT
AIM:
The aim of the study was to study the effectiveness of the complex use of bacterial therapeutic vaccine Immunovac-VP4 and allergen-specific immune therapy (ASIT) in pollinosis in children and adults. MATERIALS ANDMETHODS:
Bacterial therapeutic vaccine Immunovac-VP4 was used annually, nasal and oral administration in patients before the course of ASIT standardized aqueous-salt solutions of allergens.RESULTS:
The therapeutic application of bacterial vaccines, Immunoac-ÐÐ4 before the course ASIT has helped to reduce the frequency of acute respiratory infections in 8,5 times in comparison with the control group. Clinical efficacy of complex treatment according to the results of the survey of patients in 7 years after the start of therapy was 90%. There was a significant decrease In IgG4 to causally significant allergens, General immnunoglobulin E (IgE) and a tendency to decrease IgE.CONCLUSION:
The use of bacterial therapeutic vaccine Immunovac-VP4, which is a natural ligand of toll-like receptors in combination with ASIT, seems to be an effective and promising direction in the treatment of allergic diseases.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vacinas Bacterianas
/
Rinite Alérgica Sazonal
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Dessensibilização Imunológica
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article