Neonatal hypothyroidism despite maternal tri-iodothyronine toxicosis: a management problem?
Obstet Med
; 5(4): 178-180, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-30705701
ABSTRACT
A primigravida was referred with hyperthyroidism in early pregnancy from longstanding Graves' disease treated with propylthiouracil. She had selective elevation of free tri-iodothyronine (fT3) levels, low normal free tetra-iodothyronine (fT4) and suppressed thyroid-stimulating hormone (TSH). Given her symptoms of thyrotoxicosis and elevated TSH receptor antibodies, therapy was tailored towards maintaining clinical and biochemical euthyroidism. However the fetus developed a goitre secondary to hypothyroidism. This case highlights the dilemmas in managing maternal T3 toxicosis while aiming for a high normal fT4 to prevent fetal hypothyroidism including the role of fetal ultrasound monitoring and amniocentesis.
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MEDLINE
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En
Ano de publicação:
2012
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Article