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Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis.
Bäurle, Stefan; Nagel, Jens; Peters, Olaf; Bräuer, Nico; Ter Laak, Antonius; Preusse, Cornelia; Rottmann, Antje; Heldmann, Dieter; Bothe, Ulrich; Blume, Thorsten; Zorn, Ludwig; Walter, Daryl; Zollner, Thomas M; Steinmeyer, Andreas; Langer, Gernot.
Afiliação
  • Bäurle S; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Nagel J; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Peters O; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Bräuer N; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Ter Laak A; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Preusse C; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Rottmann A; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Heldmann D; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Bothe U; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Blume T; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Zorn L; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Walter D; Evotec (UK) Ltd. , 112-114 Innovation Drive , Milton Park, Abingdon , Oxfordshire OX14 4RZ , U.K.
  • Zollner TM; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Steinmeyer A; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
  • Langer G; Bayer AG, Research & Development, Pharmaceuticals , Müllerstrasse 178 , 13353 Berlin , Germany.
J Med Chem ; 62(5): 2541-2563, 2019 03 14.
Article em En | MEDLINE | ID: mdl-30707023
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzimidazóis / Endometriose / Receptores de Prostaglandina E Subtipo EP4 Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzimidazóis / Endometriose / Receptores de Prostaglandina E Subtipo EP4 Idioma: En Ano de publicação: 2019 Tipo de documento: Article