Age-related aqueous humor (AH) and lens epithelial cell/capsule protein carbonylation and AH protein concentration in cataract patients who have pseudoexfoliative diseases.
Mol Vis
; 24: 890-901, 2018.
Article
em En
| MEDLINE
| ID: mdl-30713426
ABSTRACT
Purpose:
The aim of this study is to investigate the age-correlation of oxidative stress (OS, assessed by the accumulative OS damage marker protein carbonyls) in aqueous humour (AH; together with protein concentration) and lens epithelial cells plus capsule (LECs/capsule) in patients with cataract (CAT), and also suffering from pseudoexfoliation syndrome (PEX), primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG).Methods:
AH samples from 78 male/female patients (21, 20, 19 and 18 with CAT, PEX, PXG, and POAG, respectively), and LECs/capsule samples from 104 male/female patients (34, 32, 18, and 20 with CAT, PEX, PXG and POAG, respectively) were collected during phacoemulsification CAT surgery. Average protein carbonyl concentrations were measured in patients grouped in 5-year age intervals (ranging from 56-60 to 86-90). The non-overlapping age ranges and numbers of the tested subjects did not allow comparative follow up studies for the tested diseases.Results:
There is an age-dependent increase of protein carbonyls in AH (nmol mg-1 protein and ml-1), and in the order CAT
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Humor Aquoso
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Catarata
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Glaucoma de Ângulo Aberto
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Síndrome de Exfoliação
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Modificação Traducional de Proteínas
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Proteínas do Olho
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Cápsula do Cristalino
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article