Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren's syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?

Blokland, Sofie L M; Hillen, Maarten R; Wichers, Catharina G K; Zimmermann, Maili; Kruize, Aike A; Radstake, Timothy R D J; Broen, Jasper C A; van Roon, Joel A G

Blokland, Sofie L M; Hillen, Maarten R; Wichers, Catharina G K; Zimmermann, Maili; Kruize, Aike A; Radstake, Timothy R D J; Broen, Jasper C A; van Roon, Joel A G.

Afiliação

Blokland SLM; Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Hillen MR; Laboratory of Translational Immunology, Department of Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Wichers CGK; Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Zimmermann M; Laboratory of Translational Immunology, Department of Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Kruize AA; Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Radstake TRDJ; Laboratory of Translational Immunology, Department of Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Broen JCA; Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
van Roon JAG; Laboratory of Translational Immunology, Department of Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.

RMD Open ; 5(1): e000701, 2019.

Article em En | MEDLINE | ID: mdl-30713717

Assuntos

Linfócitos B/imunologia; Linfócitos B/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Síndrome de Sjogren/etiologia; Síndrome de Sjogren/metabolismo; Linfócitos T/imunologia; Linfócitos T/metabolismo; Biomarcadores; Estudos de Casos e Controles; Citocinas/metabolismo; Suscetibilidade a Doenças; Expressão Gênica; Humanos; Imunofenotipagem; Ativação Linfocitária/imunologia; Alvo Mecanístico do Complexo 1 de Rapamicina/antagonistas & inibidores; Modelos Biológicos; Terapia de Alvo Molecular; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico; Glândulas Salivares/imunologia; Glândulas Salivares/metabolismo; Glândulas Salivares/patologia; Transdução de Sinais; Síndrome de Sjogren/diagnóstico; Síndrome de Sjogren/tratamento farmacológico

Palavras-chave

B cells; Sjögren's syndrome; T cells; mTOR; rapamycin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T / Síndrome de Sjogren / Alvo Mecanístico do Complexo 1 de Rapamicina Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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