Detection of Nicotine and Nicotine Metabolites in Units of Banked Blood.
Am J Clin Pathol
; 151(5): 516-521, 2019 04 02.
Article
em En
| MEDLINE
| ID: mdl-30715103
ABSTRACT
OBJECTIVES:
To determine the concentrations of nicotine and nicotine metabolites in RBC units as a means to estimate the point prevalence of exposure within the healthy donor pool.METHODS:
Segments from 105 RBC units were tested for the presence of nicotine, cotinine, or trans-3'-hydroxycotinine by liquid chromatography-tandem mass spectrometry.RESULTS:
Of the 20 (19%) units that contained detectable concentrations of nicotine, cotinine, or trans-3'-hydroxycotinine, 19 (18.1%) contained concentrations consistent with the use of a nicotine-containing product within 48 hours of specimen collection. One RBC unit contained nicotine concentrations consistent with passive exposure.CONCLUSIONS:
Chemicals from nicotine-containing products are detectable within the US RBC supply. Further investigation is needed to determine the risks of transfusion-associated exposure to nicotine and other tobacco-associated chemicals among vulnerable patient populations such as neonates.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cotinina
/
Nicotina
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article