Breakpoint to MIC quotient: A parameter to rapidly evaluate the in vitro bactericidal activity of ß-lactams on Enterobacteriaceae.
Int J Antimicrob Agents
; 53(5): 674-677, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-30716447
ABSTRACT
Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) do not completely predict the bactericidal nature of the antimicrobial agent. Patients with pathogens having MICs near the clinical breakpoint experience a higher risk of clinical failure. This study defined an indicator, breakpoint to MIC quotient (BMQ), that incorporates MIC and the European Committee on Antimicrobial Susceptibility Testing breakpoint. The BMQ was inversely correlated with MBC in antibiotic combinations against Enterobacteriaceae strains (Spearman coefficient ≤ -0.96). This new parameter may provide timely additional insight for choosing an antibiotic for a severe bacterial infection.
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Base de dados:
MEDLINE
Assunto principal:
Testes de Sensibilidade Microbiana
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Beta-Lactamas
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Enterobacteriaceae
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Viabilidade Microbiana
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Antibacterianos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article