Association study of the ABCA7 rs3752246 polymorphism in Alzheimer's disease.
Psychiatry Res
; 279: 376-377, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-30717989
ABSTRACT
The ATP-binding cassette, sub-family A, member 7 (ABCA7) gene has been identified as a strong genetic risk locus for Alzheimer's disease (AD). Our case-control study (416 AD patients and 302 controls) provides further data on the rs3752246 polymorphism in AD in the Hungarian population that has not been investigated so far regarding the ABCA7 gene variants. A modest, marginally significant association of the G allele containing genotypes with AD was observed (pâ¯=â¯0.054). In line with the previous results in other populations, the G allele carriers had an increased risk for developing AD considering C/C genotype as reference category.
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Base de dados:
MEDLINE
Assunto principal:
Transportadores de Cassetes de Ligação de ATP
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Polimorfismo de Nucleotídeo Único
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Estudos de Associação Genética
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article