Associations between daily-living physical activity and laboratory-based assessments of motor severity in patients with falls and Parkinson's disease.
Parkinsonism Relat Disord
; 62: 85-90, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30718220
ABSTRACT
INTRODUCTION:
Recent work suggests that wearables can augment conventional measures of Parkinson's disease (PD). We evaluated the relationship between conventional measures of disease and motor severity (e.g., MDS-UPDRS part III), laboratory-based measures of gait and balance, and daily-living physical activity measures in patients with PD.METHODS:
Data from 125 patients (age 71.7⯱â¯6.5 years, Hoehn and Yahr 1-3, 60.5% men) were analyzed. The MDS-UPDRS-part III was used as the gold standard of motor symptom severity. Gait and balance were quantified in the laboratory. Daily-living gait and physical activity metrics were extracted from an accelerometer worn on the lower back for 7 days.RESULTS:
In multivariate analyses, daily-living physical activity and gait metrics, laboratory-based balance, demographics and subject characteristics together explained 46% of the variance in MDS-UPDRS-part III scores. Daily-living measures accounted for 62% of the explained variance, laboratory measures 30%, and demographics and subject characteristics 7% of the explained variance. Conversely, demographics and subject characteristics, laboratory-based measures of gait symmetry, and motor symptom severity together explained less than 30% of the variance in total daily-living physical activity. MDS-UPDRS-part III scores accounted for 13% of the explained variance, i.e., <4% of all the variance in total daily-living activity.CONCLUSIONS:
Our findings suggest that conventional measures of motor symptom severity do not strongly reflect daily-living activity and that daily-living measures apparently provide important information that is not captured in a conventional one-time, laboratory assessment of gait, balance or the MDS-UPDRS. To provide a more complete evaluation, wearable devices should be considered.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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Exercício Físico
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Marcha
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Laboratórios
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article