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Effect of bifenthrin on oxidative stress parameters in the liver, kidneys, and lungs of rats.
Dar, Muneer Ahmad; Khan, Adil Mehraj; Raina, Rajinder; Verma, Pawan Kumar; Wani, Nasir Manzoor.
Afiliação
  • Dar MA; Department of Veterinary Pharmacology and Toxicology, Sher-e-Kashmir University of Agricultural Sciences and Technology, Jammu, India.
  • Khan AM; Department of Veterinary Pharmacology and Toxicology, Sher-e-Kashmir University of Agricultural Sciences and Technology, Jammu, India. adi.adilmehraj@gmail.com.
  • Raina R; Division of Veterinary Pharmacology and Toxicology, Sher-e-Kashmir University of Agricultural Sciences and Technology, Kashmir, India. adi.adilmehraj@gmail.com.
  • Verma PK; Department of Veterinary Pharmacology and Toxicology, Sher-e-Kashmir University of Agricultural Sciences and Technology, Jammu, India.
  • Wani NM; Department of Veterinary Pharmacology and Toxicology, Sher-e-Kashmir University of Agricultural Sciences and Technology, Jammu, India.
Environ Sci Pollut Res Int ; 26(9): 9365-9370, 2019 Mar.
Article em En | MEDLINE | ID: mdl-30721431
ABSTRACT
Oxidative stress inducing potential of bifenthrin was evaluated in the liver, kidney, and lung of rats following its repeated oral administration for 20 and 30 days. Bifenthrin-treated rats showed a significant lipid peroxidation in all three tissues. By 20th day of treatment, there was a significant decrease in superoxide dismutase activity of the liver, catalase and glutathione peroxidase activity of the liver and lung, and glutathione S-transferase activity of the kidney and lung. By 30th day of exposure, the activities of these enzymes were significantly decreased in all three tissues. The highest oxidative stress, indicated by lipid peroxidation and alteration in antioxidant enzymes, is produced in the liver followed by the kidney and lung. In conclusion, bifenthrin has a potential to induce severe oxidative stress in the liver, kidney, and lung. The extent of oxidative stress is increased with the duration of exposure.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Praguicidas / Piretrinas / Estresse Oxidativo Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Praguicidas / Piretrinas / Estresse Oxidativo Idioma: En Ano de publicação: 2019 Tipo de documento: Article