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The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis.
Choi, Wan-Su; Lee, Gyuseok; Song, Won-Hyun; Koh, Jeong-Tae; Yang, Jiye; Kwak, Ji-Sun; Kim, Hyo-Eun; Kim, Seul Ki; Son, Young-Ok; Nam, Hojung; Jin, Iljung; Park, Zee-Yong; Kim, Jiyeon; Park, In Young; Hong, Jeong-Im; Kim, Hyun Ah; Chun, Churl-Hong; Ryu, Je-Hwang; Chun, Jang-Soo.
Afiliação
  • Choi WS; National Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Lee G; National Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Song WH; Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju, South Korea.
  • Koh JT; Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju, South Korea.
  • Yang J; Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju, South Korea.
  • Kwak JS; National Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Kim HE; National Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Kim SK; National Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Son YO; National Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Nam H; National Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Jin I; School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Park ZY; School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Kim J; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Park IY; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Hong JI; Division of Rheumatology, Hallym University Sacred Heart Hospital, Kyunggido, South Korea.
  • Kim HA; Division of Rheumatology, Hallym University Sacred Heart Hospital, Kyunggido, South Korea.
  • Chun CH; Division of Rheumatology, Hallym University Sacred Heart Hospital, Kyunggido, South Korea.
  • Ryu JH; Department of Orthopedic Surgery, Wonkwang University School of Medicine, Iksan, South Korea.
  • Chun JS; Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju, South Korea. jesryu@jnu.ac.kr.
Nature ; 566(7743): 254-258, 2019 02.
Article em En | MEDLINE | ID: mdl-30728500
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoartrite / Esteroide Hidroxilases / Colesterol / Membro 1 do Grupo F da Subfamília 1 de Receptores Nucleares / Família 7 do Citocromo P450 Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoartrite / Esteroide Hidroxilases / Colesterol / Membro 1 do Grupo F da Subfamília 1 de Receptores Nucleares / Família 7 do Citocromo P450 Idioma: En Ano de publicação: 2019 Tipo de documento: Article