Markers of acute kidney injury in children undergoing hematopoietic stem cell transplantation.
Adv Clin Exp Med
; 28(8): 1111-1118, 2019 Aug.
Article
em En
| MEDLINE
| ID: mdl-30740947
ABSTRACT
Acute kidney injury (AKI), one of the major complications in children undergoing hematopoietic stem cell transplantation (HSCT), is an independent predictor of the patient's survival and a prognostic factor of progression to chronic kidney disease (CKD). Despite the multifaceted role of AKI, its early diagnosis in the course of HSCT remains a challenge. These difficulties may result from the inefficiency of traditional methods used to assess kidney function, like serum creatinine or estimated glomerular filtration rate. Moreover, the list of potential AKI markers tested in HSCT conditions is limited and does not involve indexes evaluated in the pediatric population. This review summarizes current knowledge on the pathophysiology of AKI developing in the course of HSCT; presents well-known markers of AKI that are potentially applicable in children who have undergone HSCT; discusses the role of new markers in diagnosing AKI and predicting the renal outcome in children undergoing HSCT; and analyzes the prospects for the use of new tools for assessing kidney injury in everyday clinical practice.
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
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Transplante de Células-Tronco Hematopoéticas
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Insuficiência Renal Crônica
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Injúria Renal Aguda
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article