Protein misfolding and aggregation in neurodegenerative diseases: a review of pathogeneses, novel detection strategies, and potential therapeutics.

Gandhi, Jason; Antonelli, Anthony C; Afridi, Adil; Vatsia, Sohrab; Joshi, Gunjan; Romanov, Victor; Murray, Ian V J; Khan, Sardar Ali

Gandhi, Jason; Antonelli, Anthony C; Afridi, Adil; Vatsia, Sohrab; Joshi, Gunjan; Romanov, Victor; Murray, Ian V J; Khan, Sardar Ali.

Afiliação

Gandhi J; Department of Physiology and Biophysics, Stony Brook University School of Medicine, 101 Nicolls Road, Health Sciences Center, Stony Brook, NY 11794-8434, USA.
Antonelli AC; Medical Student Research Institute, St. George's University School of Medicine, Grenada, West Indies.
Afridi A; Department of Pathology, Stony Brook University School of Medicine, 101 Nicolls Road, Health Sciences Center, Stony Brook, NY 11794-8434, USA.
Vatsia S; Department of Physiology and Biophysics, Stony Brook University School of Medicine, 101 Nicolls Road, Health Sciences Center, Stony Brook, NY 11794-8434, USA.
Joshi G; Department of Cardiothoracic Surgery, Lenox Hill Hospital, 130 East 77th Street, New York, NY 10075, USA.
Romanov V; Department of Internal Medicine, Stony Brook Southampton Hospital, 240 Meeting House Lane, Southampton, NY 11968, USA.
Murray IVJ; Department of Urology, Health Sciences Center T9-040, Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, NY 11794-8093, USA.
Khan SA; Department of Physiology and Neuroscience, St. George's University School of Medicine, Grenada, West Indies.

Rev Neurosci ; 30(4): 339-358, 2019 05 27.

Article em En | MEDLINE | ID: mdl-30742586

Assuntos

Doenças Neurodegenerativas; Dobramento de Proteína; Deficiências na Proteostase; Animais; Humanos; Doenças Neurodegenerativas/diagnóstico; Doenças Neurodegenerativas/tratamento farmacológico; Doenças Neurodegenerativas/patologia; Complexo de Endopeptidases do Proteassoma/metabolismo; Proteólise; Deficiências na Proteostase/diagnóstico; Deficiências na Proteostase/tratamento farmacológico; Deficiências na Proteostase/patologia; Resultado do Tratamento

Palavras-chave

amyloidogenesis; cell proteostasis network; mitochondrial dysfunction; neurodegenerative disease; protein aggregation; protein misfolding

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dobramento de Proteína / Doenças Neurodegenerativas / Deficiências na Proteostase Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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