Blood-brain barrier disruption and neuroinflammation as pathophysiological mechanisms of the diffuse manifestations of neuropsychiatric systemic lupus erythematosus.
Autoimmun Rev
; 18(4): 426-432, 2019 Apr.
Article
em En
| MEDLINE
| ID: mdl-30763633
ABSTRACT
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g., strokes, thrombotic events) to diffuse disorders affecting cognition, mood and level of consciousness (e.g. acute confusional state, psychosis). Both type of manifestations of NPSLE differ in their pathological mechanisms. The focus of this review will be on the mechanisms that lead to the blood-brain barrier (BBB) disruption and to the neuroinflammation related with the diffuse manifestations of NPSLE.
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Base de dados:
MEDLINE
Assunto principal:
Barreira Hematoencefálica
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Vasculite Associada ao Lúpus do Sistema Nervoso Central
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Encefalite
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Lúpus Eritematoso Sistêmico
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article