Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities.
Fitoterapia
; 134: 58-64, 2019 Apr.
Article
em En
| MEDLINE
| ID: mdl-30763720
ABSTRACT
Five new aromatic compounds, designed as lucidumins A-D (1-4) and lucidimine E (9), along with seven known aromatic compounds (5-8, 10-12) were isolated from Ganoderma lucidum. Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2-4 and 6-10 displayed remarkable neuroprotective activities against corticosterone-induced PC12 cell damage, with the cell viability ranging from 69.99% to 126.00%; and compounds 1-4, 9 and 10 exhibited significant anti-inflammatory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, with IC50 values ranging from 4.68 to 15.49⯵M. In particular, compound 10 showed remarkable neuroprotection with EC50 value of 2.49⯱â¯0.12⯵M, and potent anti-inflammation with IC50 value of 4.68⯱â¯0.09⯵M.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fármacos Neuroprotetores
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Ganoderma
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Anti-Inflamatórios
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article